Multivariate Analysis of Prognostic Factors in the Eldly Patients with Small Cell Lung Cancer:A Study of 160 Patients
10.3779/j.issn.1009-3419.2014.01.03
- VernacularTitle:160例老年小细胞肺癌预后多因素分析
- Author:
CHEN XIAOLING
1
;
FANG JIAN
;
NIE JUN
;
DAI LING
;
ZHANG JIE
;
HU WEIHENG
;
HAN JINDI
;
MA XIANGJUAN
;
TIAN GUANGMING
;
HAN SEN
;
WU DI
;
LONG JIERAN
;
WANG YANG
Author Information
1. 100142 北京，北京大学肿瘤医院暨北京市肿瘤防治研究所，恶性肿瘤发病机制及转化研究教育部重点实验室，胸部肿瘤内二病房
- Keywords:
Lung neoplsms;
Geriatrics;
Survival;
Prognosis
- From:
Chinese Journal of Lung Cancer
2014;(1):15-23
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about15%-20%of all lung cancer. hTe objective of this study is to evaluate the survival of patients older than 65 with SCLC and analyze the independent prognostic factors in this group of patients. Methods A retrospective study has enrolled160 cases of lung cancer aged over 65. hTe prognostic factors were analyzed by Kaplan-Meier and Cox multivariate proportional hazards model. Results ①hTe median follow-up time was12 (2-109) months.1-, 3-, and 5-year survival rate was 47.1%,13.0%, 9.6%respectively, and 74.4%, 25.0%,19.7%for limited-stage (LD), and 36.8%, 8.7%, 5.8%for extensive-stage (ED). Median survival time (MST) of all the patients was12 months, 24 months for LD and11months for ED, respectively.②Multivariate analysis suggested that performance status (PS) pre-treatment, the change of PS atfer treatment, stage, liver metastases and thoracic radiotherapy were the independent prognostic factors in all patients.③For LD-SCLC patients, PS pre-treatment, thoracic radiotherapy were the independent prognostic fac-tors. hTe model of thoracic radiotherapy (concurrent chemoradiation vs sequential chemoradiation, early concurrent chemo-radiation vs late concurrent chemoradiation) and prophylactic cranial irradiation (PCI) did not show signiifcant difference.④For ED-SCLC patients, sex, the change of PS atfer treatment, chemotherapy, liver metastases, thoracic radiotherapy, PCI were the independent prognostic factors. Conclusion hTe survival time is related to PS and thoracic radiotherapy in eldly patients. Besides, it is also related to sex, chemotherapy, liver metastases and PCI for ED-SCLC.
