Prognostic value of serum adiponectin and fibroblast growth factor-23 in patients undergoing heart valve replacement
- VernacularTitle:血清脂联素、成纤维生长因子-23在心脏瓣膜置换术患者预后中的评估价值
- Author:
Chao ZHANG
1
;
Dong HAN
;
Dikun FAN
;
Jianchao GAO
;
Kan YANG
Author Information
- Keywords: heart valve replacement; adiponectin; fibroblast growth factor-23; Acute Physi-ology and Chronic Health Evaluation Ⅱ
- From: Journal of Clinical Medicine in Practice 2024;28(3):58-62
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the prognostic value of serum adiponectin and fibroblast growth factor-23(FGF23)levels in patients undergoing cardiac valve replacement.Methods A to-tal of 98 patients undergoing heart valve replacement were selected as the study group.The patients in the study group were divided into good prognosis group(n=67)and poor prognosis group(n=31).A total of 90 healthy subjects were selected as control group.Spearman method was used to analyze the correlation of serum adiponectin and FGF23 levels with plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,respectively.Multivariate Logistic regression analysis was used to analyze the prognostic fac-tors of patients with heart valve replacement.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum adiponectin and FGF23 levels in patients with heart valve replacement.Results Serum FGF23,NT-proBNP level and APACHE Ⅱ score in the study group were significantly higher,and serum adiponectin level was significantly lower than that in the control group(P＜0.05).The levels of serum FGF23,NT-proBNP and APACHE Ⅱ score in the poor prognosis group were significantly higher,and the serum adiponectin level was significantly lower than that in the good prognosis group(P＜0.05).Serum FGF23 level was positively correlated with NT-proBNP level and APACHE Ⅱ score(P＜0.05).Serum adiponectin level was negatively corre-lated with NT-proBNP level and APACHE Ⅱ score(P＜0.05).The levels of serum adiponectin,FGF23,NT-proBNP and APACHE Ⅱ score were the influencing factors for the prognosis of patients with heart valve replacement(P＜0.05).The area under the curve(AUC)of serum adiponectin and FGF23 for predicting the prognosis of patients undergoing cardiac valve replacement was 0.862 and 0.807,respectively,and the AUC of the combined prediction was 0.911.The AUC of com-bined prediction of adiponectin and FGF23 was higher than that of individual prediction(P＜0.05).Conclusion The combination of serum adiponectin and FGF23 has a good effect in predic-ting the prognosis of patients with heart valve replacement.Serum adiponectin and FGF23 are expec-ted to be effective indicators for evaluating the prognosis of patients undergoing heart valve replace-ment.
