A case report with anti-IgLON family member 5 antibody-related encephalopathy
10.7619/jcmp.20233402
- VernacularTitle:1例抗IgLON家族蛋白5抗体相关脑病的病例报告
- Author:
Yong PENG
1
;
Cancan MA
;
Lin ZHU
;
Beilei CHEN
;
Mengmei YIN
;
Jian WU
;
Long YU
;
Wenzhe HOU
Author Information
1. 扬州大学医学院,江苏扬州,225009
- Keywords:
autoimmune encephalitis;
anti-IgLON family member 5 antibody-related encepha-lopathy;
cognitive disorder;
sleep disorder;
epilepsy;
immunotherapy
- From:
Journal of Clinical Medicine in Practice
2024;28(2):55-59
- CountryChina
- Language:Chinese
-
Abstract:
This study reported a 50-year-old female patient who was diagnosed with anti-IgLON family member 5(anti-IgLON5)antibody-related encephalopathy,presented with cognitive and sleep disorders,autonomic dysfunction and seizures,positive serum IgLON5 antibody but negative cerebro-spinal fluid IgLON5 antibody,negative human leukocyte antigen(HLA)by genetic testing,and was diagnosed as anti-IgLON5 antibody-related encephalopathy.After hospital admission,the patient was given intravenous methylprednisolone combined with immunoglobulin immunotherapy,donepezil for improvement of cognition,sodium valproate and oxcarbazepine for prevention and treatment of epilep-tic seizures,and finally her symptoms improved significantly.
