The impact of digital subtraction angiography guided neurointerventional thrombectomy combined with intravenous thrombolysis by tirofiban in acute cerebral infarction patients
- VernacularTitle:数字减影血管造影引导下神经介入取栓联合替罗非班静脉溶栓对急性脑梗死患者的影响
- Author:
Zhongkui HAN
1
;
Liujun SUO
;
Yonghui WANG
;
Yuanliang XIA
Author Information
- Keywords: digital subtraction angiography; neurointerventional thrombus removal; tirofi-ban; intravenous thrombolysis; acute cerebral infarction
- From: Journal of Clinical Medicine in Practice 2024;28(2):8-12
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the impact of digital subtraction angiography(DSA)-guided neurointerventional thrombus removal combined with intravenous thrombolysis by tirofiban on the rate of recanalization of blood vessels,endothelial function,hemodynamics,and the degree of neurological deficit in patients with acute cerebral infarction.Methods Eighty patients with acute cerebral infarc-tion were selected as study subjects and randomly divided into observation group and control group u-sing the random number table method,with 40 patients in each group.The control group was treated with DSA-guided neurointerventional thrombus removal,and the observation group was treated with in-travenous thrombolysis with tirofiban on the basis of the control group.The rates of recanalization of blood vessels,endothelial function index levels,hemodynamic index levels,and the degree of neuro-logical deficit were compared between the two groups.Results The rates of recanalization of blood vessels in the observation group and control group were 90.00％(36/40)and 65.00％(26/40),re-spectively,with a significant difference(P＜0.05).After treatment,the serum endothelin-1(ET-1)levels in both groups were lower than those before treatment,and the nitric oxide(NO)levels were higher than those before treatment,and the ET-1 level in the observation group was lower than that in the control group,and the NO level was higher than that in the control group(P＜0.05).After treatment,the carotid extracranial resistance and characteristic impedance in both groups were lower than those before treatment,and the mean blood flow and mean blood flow velocity were higher than those before treatment,and the carotid extracranial resistance and characteristic impedance in the observation group were lower than those in the control group,and the mean blood flow and mean blood flow velocity were higher than those in the control group(P＜0.05).After treatment,the Na-tional Institutes of Health Stroke Scale(NIHSS)scores in both groups were lower than those before treatment,and the NIHSS score in the observation group was lower than that in the control group(P＜0.05).Conclusion DS A-guided neurointerventional thrombus removal combined with intra-venous thrombolysis by tirofiban can effectively increase the rate of recanalization of blood vessels in patients with acute cerebral infarction,improve endothelial function,alleviate neurological deficit symptoms,increase blood flow velocity and blood flow at ischemic lesion sites,and reduce carotid extracranial resistance and characteristic impedance.
