Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation
10.3779/j.issn.1009-3419.2013.08.07
- VernacularTitle:二甲双胍通过激活腺苷酸活化蛋白激酶（AMPK）的抗肿瘤机制
- Author:
CHEN ZHAOYU
1
;
WANG LIANTANG
;
CHEN YANYANG
Author Information
1. 中山大学中山医学院
- Keywords:
Metformin;
Antitumor mechanism;
Adenosine monophosphate-activated protein kinase (AMPK);
Metabolism;
Cell cycle arrest;
Oxidative stress;
Transformation of cancer/tumor stem cells
- From:
Chinese Journal of Lung Cancer
2013;(8):427-432
- CountryChina
- Language:Chinese
-
Abstract:
Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metformin could inhibit the growth, proliferation and transformation of cancer cells in metabolic pathways, cell cycle, oxidative stress and cancer/tumor stem cells transformation via AMPK pathway activation. But the antitumor effect of metformin via AMPK activation still exists arguments, and the deifnite mechanism remains to be further investigated and conifrmed by extensive clinical trials.
