Expression and Related Factors of Galectin-3 in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2013.08.05
- VernacularTitle:半乳凝素-3在非小细胞肺癌中的表达及相关性研究
- Author:
LIU MEIYAN
1
;
DU BING
;
LI CHUNHONG
;
ZHAO YANBIN
;
MENG QINGWEI
;
CAI LI
Author Information
1. 哈尔滨医科大学附属肿瘤医院内四科
- Keywords:
Lung neoplasms;
Galectin-3;
Apoptosis
- From:
Chinese Journal of Lung Cancer
2013;(8):417-421
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Galectin-3 is involved in many physical and pathologic process, and is closely correlated with tumorigenesis, development and metastasis. hTe aim of this study is to investigate the gene expression and signiifcance of Galectin-3 in normal lung tissue and non-small cell lung cancer (NSCLC) tissue. Methods Gene expres-sion was examined using the immunohistochemical S-P method in 62 NSCLC cases and in 17 cases with normal lung tissue. RT-PCR veriifed the expression of Galectin-3 at the transcriptional level. Results hTe expression rate of Galectin-3 in NSCLC tissue was 83.8%(52/62), which was signiifcantly higher than that in normal lung tissue (P<0.01). Galectin-3 expression was not correlated with sex (χ2=0.113, P>0.05), age (χ2=0.220, P>0.05), and histological type (χ2=0.012, P>0.05), but was nega-tively correlated with pathological differentiation (r=-0.292, P<0.05) and positively correlated with the clinical stage (r=0.336, P<0.05) in NSCLC tissue. RT-PCR results showed that the expression level of Galectin-3 in NSCLC tissue was signiifcantly higher than in normal lung tissue. Conclusion Galectin-3 may be useful in lung cancer diagnosis and may increase diagnosis rate when combined with other lung cancer markers.
