Effect of hyperglycemia on mortality rates in critically ill children.
10.3345/kjp.2010.53.3.323
- Author:
Seonguk KIM
1
;
Bo Eun KIM
;
Eun Ju HA
;
Mi Young MOON
;
Seong Jong PARK
Author Information
1. Department of Pediatrics, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea. drpsj@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Hyperglycemia;
Child;
Pediatric Intensive care unitm;
Pediatric;
Mortality;
Survival
- MeSH:
Blood Glucose;
Child;
Critical Illness;
Glucose;
Humans;
Hyperglycemia;
Intensive Care Units;
Prognosis;
Retrospective Studies
- From:Korean Journal of Pediatrics
2010;53(3):323-328
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To verify the effect of hyperglycemia on mortality rates in critically ill children and to identify the blood glucose level that influences prognosis. METHODS: From July 2006 to June 2008, a total of 206 patients who were admitted to the pediatric intensive care unit (PICU) at Asan Medical Center and who survived for more than 7 days were retrospectively reviewed. We analyzed the maximum glucose value within 7 days in PICU, PRISM-III score and SOFA score within 24 hours, and mortality. We did not perform an adjustment analysis of drugs affecting glucose level. RESULTS: The maximum glucose level within 7 days in PICU was higher in the nonsurvival group than in the survival group. Using 4 cutoff values (125, 150, 175, and 200 mg/dL), the mortality of patients with hyperglycemia was found to be 13.0%, 14.4%, 19.8%, and 21.1%, respectively, and the cutoff values of 175 and 200 mg/dL revealed significant differences in mortalities between the hyperglycemic and normoglycemic groups. The PRISM-III score was not significantly different between the hyperglycemic and normoglycemic groups under a glucose cutoff value of 175 mg/dL, but the SOFA score was higher in the hyperglycemic group. Under a glucose cutoff value of 200 mg/dL, the PRISM-III score was higher in the hyperglycemic group, and the SOFA score did not differ between the 2 groups. CONCLUSION: Hyperglycemia with a maximal glucose value > or = 175 mg/dL during the first 7 days after PICU admission was associated with increased mortality in critically ill children.
