Clinical significance of FOXM1 and Gli-1 protein expression in high-grade ovarian serous carcinoma
10.3760/cma.j.issn.0253-3766.2016.12.005
- VernacularTitle:卵巢高级别浆液性腺癌组织中叉头框转录因子M1和Gli-l蛋白表达的临床意义
- Author:
Jun ZHANG
1
;
Zhiyan LI
;
Xiaojin DUAN
;
Xiaomei FAN
;
Weina LIU
;
Yuehong LI
Author Information
1. 河北医科大学第四医院妇科
- Keywords:
Subject words] Ovarian neoplasms;
Forkhead box M1;
Gli-l;
Immunohistochemistry;
Prognosis
- From:
Chinese Journal of Oncology
2016;38(12):904-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the different expression and prognostic significance of forkhead box M1 ( FOXM1) and Gli?l in ovarian high grade serous carcinoma ( HGSC) . Methods The expressions of FOXM1 and Gli?1 in 94 cases of HGSC and 20 cases of normal fallopian tube tissues were detected by immunohistochemistry. Kaplan?Meier analysis and Cox multivariate survival analysis were used to assess the relationship of the FOXM1 and Gli?1 levels with age, International Federation of Gynecology and Obstetrics ( FIGO) stage, omental metastasis, and residual foci and prognosis of HGSC. Results The positive rates of FOXM1 and Gli?1 expression in HGSC were 79.8% (75/94) and 77.7% (73/94), respectively, both significantly higher than those of the normal controls ( P<0.05) . The expressions of FOXM1 and Gli?1 were significantly correlated with FIGO stage, and both of their positive rates in stage Ⅲ-Ⅳpatients were significantly higher than those in stage Ⅰ-Ⅱ cases ( P<0.001) . The expressions of FOXM1 in HGSC were positively correlated with Gli?1. Kaplan?Meier analysis revealed that the 5?year overall survival rates of FOXM1?and Gli?1?positive groups were 8.0% and 6.8%, significantly lower than 36.8% and 38.1% of the FOXM1?and Gli?1?negative groups, respectively ( P<0. 05 for both ) . Cox multivariate survival analysis revealed that FIGO stage and overexpression of FOXM1 protein were independent prognostic factors of HGSC patients ( P<0.05 for both) . Conclusions The overexpression of FOXM1 and Gli?1 proteins participate in the carcinogenesis of HGSC, and are significantly associated with FIGO stage. The protein expression of FOXM1 is positively correlated with Gli?1 in HGSC. Expression of FOXM1 protein and FIGO stage are independent prognostic factors of HGSC.
