Preliminary evaluation of PET-CT and DWI for the detection of lymphoma bone marrow infiltration
10.3760/cma.j.issn.0253-3766.2016.11.011
- VernacularTitle:正电子发射计算机体层摄影和磁共振扩散加权成像评价淋巴瘤骨髓浸润的初步研究
- Author:
Yuan WU
1
;
Liping SU
;
Xiaotang YANG
;
Jianxin ZHANG
;
Ming ZHAO
;
Zong ZHANG
;
Tao GUAN
;
Xiaolan LIU
;
Yuping ZHENG
;
Weie HAN
Author Information
1. 山西医科大学附属肿瘤医院血液科
- Keywords:
Subject words] Lymphoma;
Bone marrow;
Diagnosis;
Positron emission tomography-computed tomography;
Diffusion weighted imaging
- From:
Chinese Journal of Oncology
2016;38(11):853-860
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of PET-CT and DWI for the detection of bone marrow infiltration of lymphoma .Methods The bone marrow samples of 93 untreated patients with pathologically diagnosed lymphoma were retrospectively analyzed . 61 patients underwent PET-CT examination, and other 32 underwent DWI examination .With bone marrow biopsy results as “gold standard”, the rates and sites of bone marrow infiltration of various lymphoma subtypes were analyzed , and the detection rates of the two imaging techniques were compared according to different lymphoma subtypes . Results 39 patients were diagnosed as bone marrow infiltration based on pathological examination of bone marrow biopsies from routine sampling sites and bone marrow pathological examination of biopsies guided by PET-CT and DWI.The sensitivity, specificity, accuracy, positive and negative predictive values of PET-CT for lymphoma bone marrow infiltration were 80.8%, 88.6%, 85.3%, 84.0%and 86.1%, respectively; for DWI examination, these rates were 84.6%, 89.5%, 87.5%, 84.6%and 89.5%, respectively.The detection rates of the two imaging techniques for aggressive lymphoma were 37.5%(18/48) and 38.1%(8/21), respectively, which were slightly higher than those for the indolent lymphoma [23.1%(3/13) and 27.3%(31/1)], although the differences were not statistically significant (P=0.521, P=0.660).For both aggressive lymphoma and indolent lymphoma , the detection rates of DWI were numerically slightly higher than those of PET-CT(P=0.963, P=1.000).Conclusions PET-CT and DWI have important and similar diagnostic value for bone marrow infiltration of lymphoma .None of PET-CT and DWI can replace bone marrow biopsy (BMB).However, image-guided bone marrow biopsies can improve the detection rate of bone marrow infiltration of lymphoma .
