Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2009.07.008
- VernacularTitle:肝素酶及Ki-67在非小细胞肺癌中的表达及临床意义
- Author:
SONG ZUOQING
1
;
XU XIAOHONG
;
WEI SEN
;
CHEN JUN
;
LIU YI
;
LI XIN
;
ZHAO HONGLIN
;
QIU XIAOMING
;
ZHOU NAIKANG
Author Information
1. 天津医科大学总医院
- Keywords:
Lung neoplasms;
Heparanase;
Ki-67;
Immunohistochemistry
- From:
Chinese Journal of Lung Cancer
2009;12(7):785-788
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective It has been proven that heparanase and Ki-67 had relationship with occur-rence and metastasis in lung cancer. The aim of this work was to investigate the expressions of heparanase and Ki-67 and to ex-plore their clinical significance and mutual relations in non-small cell lung cancer (NSCLC). Methods Immunohistochemical method was used to detect the heparanase and Ki-67expression in the routinely paraffin-embedded sections of surgical specimen of 70 cases with NSCLC and 20 ones with normal lung tissues. Results Heparanase and Ki-67 were highly expressed in lung cancer tissues (72.996 and 85.796) while negative in epithelia of normal lung tissues. The expression of heparanase was signifi-cantly correlated with TNM stage (P=0.044) and lymphatic metastasis (P=0.001). The expression of Ki-67 was significantly cor-related with tumor size (P=0.03) and histology type (P=0.001) and differentiation (P=0.01) and lymphatic metastasis (P=0.01) and TNM stage (P=0.043). The expression ofhaparanase and Ki-67 was no significant difference (P=0.323). Conclusion Hepa-ranase and Ki-67 were involved in the occurrence and development of lung cancer and they may predict patients prognosis, while the expression of heparanase and Ki-67 had no association with NSCLC, which may contribute to the different mechanisms involved in tumor occurrence and development.
