Clinical Observation on the Target Therapy of Rh-Endostin, Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer
10.3779/j.issn.1009-3419.2009.07.007
- VernacularTitle:重组人血管内皮抑素靶向治疗晚期非小细胞肺癌的临床研究
- Author:
MU HAIYU
1
;
SHEN CHUNYAN
;
FENG YILING
Author Information
1. 武警医学院附属医院
- Keywords:
rh-Endostin;
Target therapy;
Lung neoplasms;
Chemotherapy
- From:
Chinese Journal of Lung Cancer
2009;12(7):780-784
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective The chemotherapy of advanced non-small cell lung cancer is in a Bottleneck. The target therapy of Anti-angiogenesis gradually shows an advantage in the therapy of patients with advanced NSCLC. To in-vestigate the short-term efficacy, safety and the quality of life of the target therapy of rh-Endostin combined with chemotherapy in patients with advanced NSCLC. Methods Sixty-two advanced NSCLC patients were randomly divided into either the trial group with chemotherapy plus rh-Endostin or control group with chemotherapy alone. The efficacy and toxicity were evaluated after 2 cycles according to RECIST criteria. Results The trial groups efficiency rate was 46.8796, while the control group was 26.6696, there was no significant differences of two groups (χ2=1.912, P=0.166). The clinical benefit rate was 81.259% in the trial group and 53.339% in control group. There was significant difference of the clinical benefit rate between the trial group and the control group (χ2=4.3185, P=0.0377). The score of quality of life in the trial group was significantly higher than that the control group after the treatment (χ2= 11.233, P=0.0008). There was no significant difference of incidence of toxicities between the trial group and the control group (P>0.05). Conclusion Rh-Endostin combined with chemotherapy was effective, reasonable, safe and well tolerated for advanced NSCLC.
