The Correlation between CT Characteristics of Non-small Lung Cancer and the Perfor- mance of 18F-FDG PET and the Expression of Glut1 Protein
10.3779/j.issn.1009-3419.2009.07.005
- VernacularTitle:非小细胞肺癌的CT征象与18F-FDGPET表现、Glutl表达的关系
- Author:
TIAN MOHAN
1
;
YU LIJUAN
;
DUAN YU
;
WANG XIN
Author Information
1. 哈尔滨医科大学附属肿瘤医院
- Keywords:
Lung neoplasms;
Tomography;
PET computed;
18F-2-fluoro-deoxT-D-glucose;
lmmunohistochemicaltechnique;
Glutl protein
- From:
Chinese Journal of Lung Cancer
2009;12(7):770-774
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Glutl is the main carrier which intervenes the glucose uptake of cell, and the expression of Glutl was positively correlated to the uptake of FDG. The aim of this study is to select the CT characteristics and clinicopathological parameters which can refect the levels of glucose metabolism of human non-small lung cancer (NSLC). Methods Thirty-three cases of the NSLC (squamous carcinoma 11 cases and adenocarcinoma 22 cases) have undergone the scanning of FDG PET/CT before operation. The tumor pathological classification, degree of differentiation and lymph node me-tastasis were collected. The CT characteristics which included the diameter, deep lobulation, thin and short spiculation, spinous protuberance, cavity sign, vessel convergence sign and pleural retraction sign were described. Tracer uptake of suspected lesious was assessed by visual assessment and quantitatively by the maximum standardized uptake values (SUVmax).The expression of Ghitl which were examined by means of SP immunohistochemical technique was also analyzed. Results The positive rate of Glut1 was 66.67% (squamous carcinoma was 90.91% and adenocarcinoma was 54.55%). The positive rate of Glut1 and SUVmax of squamous carcinoma were significant higher than adenocarcinoma (Pbilateral=0.037, Punilateral=0.045). Through visual assess-ment and SUVmax, the uptake and the positive rate of Glutl which size ≥2 cm were higher than the size <2 cm (Pbilateral=0.002,Pbilateral=0.001, Punilateral=0.049). The uptake intense of FDG was related to the thin and short spiculation through visual assessment(Pbilateral=0.006). Conclusion The study suggested that the levels of glucose metabolism of squamous carcinoma higher than ad-enocarcinoma, the diameter upper than 2 cm and the thin and short speculation were higher.
