DNA Expression Profiles of Non-Small Cell Lung Cancer
10.3779/j.issn.1009-3419.2009.01.002
- VernacularTitle:非小细胞肺癌的DNA表达谱
- Author:
AU Siu-Kie JOSEPH
;
CHO Chi-Shing WILLIAM
;
CHOW SHEUNG-CHUN
;
YANG MENGSU
- Keywords:
Microarray;
DNA expression profiling;
Lung neoplasms;
Biomarkers;
Epidermal growth fac-tor receptor(EGFR) mutation;
Smoking;
Personalized medicine
- From:
Chinese Journal of Lung Cancer
2009;12(1):8-15
- CountryChina
- Language:Chinese
-
Abstract:
DNA expression profiling using microarray technology has been applied to studies on the molecular classification of lung cancers, pathogenetic alterations in gene expressions and cellular path-ways, prediction of prognosis and metastasis, customized therapies, and drug development. Due to the wide variation in technical factors, different cohorts of patients and biological heterogeneity, the major hur-dle to successful clinical application is lack of robustness, reliability and reproducibility of data. With better standardization and better analytic approaches to cut down the noises from the high dimensionality of data, microarray technologies may be ready to make its way to the doctor's office with contribution to personal-ized treatment of lung cancer in the future.
