Expression of MDR1-mRNA, MRP-mRNA and LRP-mRNA in patients with non-small cell lung cancer
- VernacularTitle:非小细胞肺癌MDR1-mRNA、MRP-mRNA及LRP-mRNA表达的研究
- Author:
Junlan YANG
1
;
Weimin DAI
;
Tingzhang SHI
;
Xiufang WEI
Author Information
1. General Hospital of PLA
- From:
Chinese Journal of Lung Cancer
2001;4(3):175-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of multidrug resistance （MDR1）, multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) genes in patients with non-small cell lung cancer (NSCLC). Methods Expression of MDR1, MRP and LRP genes was detected in 30 NSCLC patients by RT-PCR method. Results The positive rates of MDR1 expression were 40％ and 16.67％ respectively in lung cancer tissues and normal lung tissues (P＝0.045), and it was not associated with the degree of cell differentiation, histological classification and the clinical stage. The positive rates of MRP expression were 43.33％ and 26.67％ respectively in lung cancer tissues and normal lung tissues. Its expression was related to degree of cell differentiation (P＝0.03), but not to the histological classification and the clinical stage. LRP expression of lung cancer tissues (56.67％) was much higher than that of normal tissues (P＝0.000?4), and it was not associated with degree of cell differentiation, histological classification and the clinical stage. Of the 30 lung cancer specimens, 7 expressed all the three kinds of genes, and 10 expressed none of them. The coincident rate was 56.67％. Conclusion The results suggest that MDR1, MRP and LRP gene may play important roles in drug resistance in NSCLC.
