Effect of Yiqi Tongluo Anshen Recipe combined with statins on coronary blood flow and blood pressure in patients with coronary heart disease and hypertension
- VernacularTitle:益气通络安神方联合他汀类药物治疗冠心病合并高血压病对患者冠状动脉血流及血压的影响
- Author:
Jinxia WANG
1
;
Juxin WANG
;
Jing LIU
;
Chang GENG
Author Information
- Keywords: Yiqi Tongluo Anshen Recipe; amlodipine; atorvastatin calcium tablet; coronary heart disease; high blood pressure; coronary blood flow
- From: Journal of Clinical Medicine in Practice 2023;27(23):43-46,53
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the effect of Yiqi Tongluo Anshen Recipe combined with statins on coronary blood flow and blood pressure in patients with coronary heart disease complicated with hy-pertension.Methods A total of 120 patients with coronary heart disease combined with hypertension were selected as study objects,and were divided into two groups according to treatment methods,with 60 patients in each group.The conventional group was treated with amlodipine tablets combined with atorvastatin calcium tablets,and the Anshen prescription group was treated with Yiqi Tongluo Anshen Recipe on the basis of the conventional group.The levels of Salusin-β,lipoprotein-associated phospho-lipase A2(LP-PLA2),high-sensitivity C-reactive protein(hs-CRP),pentamylin 3(PTX3),tumor necrosis factor-α(TNF-α)and blood pressure of the two groups were recorded before and after treat-ment,and the TIMI3 rate of coronary blood flow in myocardial infarction thrombolysis test(TIMI)and the adverse reaction rate during treatment were analyzed.Results The total effective rate of TCM syn-drome in the Anshen prescription group was higher than that in conventional group(P＜0.05).After treatment,systolic blood pressure(SBP)and diastolic blood pressure(DBP)in two groups were lower than before treatment,and SBP and DBP in the Anshen prescription group were lower than those in the conventional group(P＜0.05).The rate of coronary blood flow TIMI3 in the Anshen prescrip-tion group was higher than that in the conventional group(P＜0.05).After treatment,levels of Sa-lusin-β,LP-PLA2,PTX3,hs-CRP and TNF-α in two groups were decreased compared with those before treatment,and levels of Salusin-β,LP-PLA2,PTX3,hs-CRP and TNF-α levels of in the Anshen prescription group after treatment were lower than those in the conventional group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the Anshen prescription group and the conventional group(P＞0.05).Conclusion Yiqi Tongluo Anshen Recipe combined with statins in the treatment of coronary heart disease with hypertension can reduce the expression of related factors,improve coronary blood flow and the curative effect.
