Feasibility analysis of sentinel lymph node biopsy in patients with breast cancer after local lumpectomy
10.3760/cma.j.issn.0253-3766.2013.10.011
- VernacularTitle:乳腺肿物局部切除术后乳腺癌前哨淋巴结活检的可行性分析
- Author:
Jie WANG
1
;
Xin WANG
;
Wenyan WANG
;
Jiaqi LIU
;
Zeyu XING
;
Xiang WANG
Author Information
1. 100021,国家癌症中心 中国医学科学院北京协和医学院肿瘤医院乳腺外科
- Keywords:
Subject words] Breast neoplasms;
Sentinel lymph node biopsy;
Feasibility studies;
Local lumpectomy
- From:
Chinese Journal of Oncology
2016;38(7):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility, safety and clinical application value of sentinel lymph node biopsy( SLNB) in patients with breast cancer after local lumpectomy. Methods Clinical data of 195 patients who previously received local lumpectomy from January 2005 to April 2015 were retrospectively analyzed. All the patients with pathologic stage T1?2N0M0 ( T1?2N0M0) breast cancer underwent SLNB. Methylene blue, carbon nanoparticles suspension, technetium?99m?labeled dextran, or in combination were used in the SLNB. The interval from lumpectomy to SLNB was 1?91 days ( mean, 18. 3 days ) and the maximum diameter of tumors before first operation was 0.2?4.5 cm ( mean, 1.8 cm) . Results The sentinel lymph node was successfully found in all the cases and the detection rate was 100%. 42 patients received axillary lymph node dissection ( ALND) , 19 patients had pathologically positive sentinel lymph node, with an accuracy rate of 97.6%, sensitivity of 95.0%, false negative rate of 5.0%, and specificity of 100%, and the false positive rate was 0. Logistic regression analysis suggested that the age of patients was significantly associated with sentinel lymph node metastasis after local lumpectomy. Conclusions For early breast cancer and after breast tumor biopsy, the influence of local lumpectomy on detection rate and accuracy of sentinel lymph node is not significant. Sentinel lymph node biopsy with appropriately chosen tracing technique may still provide a high detection rate and accuracy.
