The expression of p16 and Rb proteins in non-small cell lung cancer
- VernacularTitle:p16和Rb基因产物在非小细胞肺癌的表达
- Author:
Xinyun WANG
1
;
Yuhao LI
;
Jianwen QIN
;
Hui ZHAO
;
Tianru ZHAO
Author Information
1. Tianjin Medical University
- From:
Chinese Journal of Lung Cancer
2001;4(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of p16, Rb proteins and their relationship. Methods The expression of p16, Rb in 74 cases of NSCLC and 10 cases of normal lung tissues were studied by SP immunohistochemical technique. Results p16 protein deletion rate in NSCLC was 45.95％, which was higher than that in normal lung tissue （P＜0.01）. p16 protein deletion correlated remarkably with lymph node metastasis（P＜0.01）. Rb protein deletion rate in NSCLC was 28.38％. No significant correlation of Rb deletion rate was found between NSCLC and normal lung tissues （P＞0.05）. p16 expression showed negative correlation with Rb expression（P＜0.05）. Conclusion p16 deletion may play an important role in the tumorigenesis and metastasis of NSCLC. There may be a negative feedback pathway between p16 and Rb.
