Analysis of the survival of 123 patients with intrahepatic cholangiocarcinoma after surgical resection
10.3760/cma.j.issn.0253-3766.2016.06.012
- VernacularTitle:123例肝内胆管癌患者手术切除后的生存分析
- Author:
Chao BI
1
;
Liming WANG
;
Songlin AN
;
Jing HUANG
;
Ruimei FENG
;
Fan WU
;
Weiqi RONG
;
Jianxiong WU
Author Information
1. 100021,国家癌症中心 北京协和医学院中国医学科学院肿瘤医院腹部外科
- Keywords:
Bile duct neoplasms;
Surgical procedures,operative;
Prognosis;
Carcinoembryonic antigen
- From:
Chinese Journal of Oncology
2016;38(6):466-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors for patients with intrahepatic cholangiocarcinoma after surgical resection. Methods The clinicopathological and follow?up data of 123 patients with intrahepatic cholangiocarcinoma who underwent surgical resection in Cancer Hospital, Chinese Academy of Medical Sciences between January 1999 and June 2015 were collected and reviewed, and their survival and prognosis were analyzed with the Kaplan?Meier method and Cox regression model. Results The median follow?up time was 22 months and median recurrence?free survival time was 8.97 months. The 1?, 2?and 3?year recurrence rates were 58. 6%, 68. 9% and 76. 5%, respectively. Cox multivariate regression analysis showed that preoperative rise in CEA, lymph node metastasis, multiple lesions, extrahepatic invasion, and combination of tumor necrosis were significant adverse prognostic factors affecting the postoperative recurrence?free survival in patients with intrahepatic cholangiocarcinoma after surgical resection (P<0.05 for all). The median overall survival time was 21.17 months, and the 1?, 3? and 5?year overall survival rates were 76.6%, 33.2% and 26.1%, respectively. The Cox multivariate regression analysis showed that preoperative rise in CEA, lymph node metastasis, multiple lesions, and extrahepatic invasion were significant adverse prognostic factors affecting the postoperative overall survival in patients with intrahepatic cholangiocarcinoma after surgical resection( P<0.05 for all) . Conclusion Preoperative rise in CEA, lymph node metastasis, multiple lesions and extrahepatic invasion are significant adverse prognostic factors for patients with intrahepatic cholangiocarcinoma after surgical resection.
