Effect of Hongyu Peizhen Granule on inflammatory indicators in sepsis patients differentiated as pathogen involving Qifen
10.7619/jcmp.201908024
- VernacularTitle:红玉赔赈颗粒对脓毒症气分证患者炎症指标的干预效果
- Author:
Lei ZHAO
1
;
Liang ZHU
;
Jinqi JIANG
;
Mengwen SHEN
;
Fenghua QIAN
;
Yiming QIAN
Author Information
1. 上海中医药大学附属岳阳中西医结合医院
- Keywords:
sepsis;
Hongyu Peizhen Granule;
inflammation index;
Qifen syndrome
- From:
Journal of Clinical Medicine in Practice
2019;23(8):85-87,91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of Hongyu Peizhen Granule on inflammatory indicators such as white blood cell (WBC), neutrophil percentage (N％), hypersensitive C reaction protein (hs-CRP), erythrocyte sedimentation rate (ESR), serum procalcitonin (PCT), arterial blood lactic acid (Lac) in sepsis patients. Methods Seventy acute and critical illness patients in accordance with the diagnostic criteria of sepsis were randomly divided into two groups. The patients of two groups were all given routine western medicine treatment, the experimental group was orally or nasally given Hongyu Peizhen Granule for 7 consecutive days in addition, while the control group additionally received 1/10 dose of Hongyu Peizhen Granule as placebo. The serum levels of WBC, N％, hs-CRP, ESR, PCT and Lac in arterial blood before treatment, and at 1, 3, 7 d after treatment were measured. Results Compared with the control group, the levels of N％, hs-CRP, ESR, PCT, arterial blood Lac at 7 d in the experimental group decreased more significantly (P ＜ 0. 05). Conclusion Hongyu Peizhen Granule can inhibit the inflammatory reaction of sepsis patients and improve their hyperlacticemia caused by tissue hypoxia and hypoperfusion thereby improving the prognosis of sepsis patients.
