Clinical Efficacy of Maiwei Yangfei Decoction in the Treatment of Idiopathic Pulmonary Fibrosis of Qi-Yin Deficiency Type
10.14148/j.issn.1672-0482.2024.0962
- VernacularTitle:麦味养肺汤治疗气阴两虚型特发性肺纤维化的临床疗效
- Author:
Dongwei ZHU
1
,
2
;
Qi ZHAO
;
Le BAI
;
Tingyu PAN
;
Jing WANG
;
Shenhao GUO
;
Yong XU
;
Xianmei ZHOU
Author Information
1. 南京中医药大学附属医院,江苏 南京 210029
2. 南京中医药大学第一临床医学院,江苏 南京 210023
- Keywords:
Maiwei Yangfei Decoction;
idiopathic pulmonary fibrosis;
qi-yin deficiency syndrome;
sialoglycoprotein antigen;
6-minute walking distance;
transcutaneous blood oxygen saturation;
lung function;
safety
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2024;40(9):962-969
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the therapeutic effect and safety of Maiwei Yangfei Decoction(MWYF)in the treatment of idiopathic pulmonary fibrosis of qi-yin deficiency type.METHODS A total of 58 patients with idiopathic pulmonary fibrosis of qi-yin deficiency type were randomly divided into an experimental group and a control group with 29 cases in each group according to a 1:1 ratio.Two cases dropped out of the experimental group and three cases dropped out of the control group.The control group received standardized treatment of Western medicine,and the experimental group received MWYF on the basis of the treatment of the control group.The treatment course of both groups was 3 months.The TCM syndrome score,lung function,6-minute walking distance(6MWD),transcutaneous blood oxygen saturation(SpO2),high-resolution computed tomography(HRCT)score,St.George's respir-atory questionnaire(SGRQ)score and serum sialoglycoprotein antigen(KL-6)level of the two groups were compared before and after treatment.Blood routine and liver and kidney function of the two groups were detected before and after treatment,and the occurrence of adverse reactions during treatment was recorded.RESULTS After treatment,the total score of TCM syndrome of the two groups was significantly improved(P<0.01),and the experimental group was better than the control group(P<0.01);the DLCO%of the experi-mental group increased(P<0.05),and the experimental group was higher than the control group(P<0.05).The experimental group showed significant improvement in 6MWD,HRCT grid shadow,SGRQ symptom score and total score,and serum KL-6 level(P<0.05,P<0.01),which was better than the control group(P<0.05,P<0.01).No serious adverse events occurred in either group dur-ing the treatment.CONCLUSION MWYF combined with standardized Western medicine treatment can effectively improve the clini-cal symptoms of patients with idiopathic pulmonary fibrosis of qi-yin deficiency type,reduce the expression level of serum KL-6,and has a definite effect and good safety.
