Application of DNA-image cytometryi n the diagnosis of lung cancer
10.3760/cma.j.issn.0253-3766.2016.02.007
- VernacularTitle:细胞 DNA 定量分析技术在肺癌诊断中的应用价值
- Author:
Wei TAO
1
;
Jun LI
;
Liuliu CHENG
Author Information
1. 安徽医科大学第一附属医院肿瘤内科
- Keywords:
Lung neoplasms;
Diagnosis;
DNA-image cytometry;
Liquid-based cytology;
Bronchoalveolar lavage fluid;
Bronchial brushing cytology
- From:
Chinese Journal of Oncology
2016;38(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of DNA-image cytometry (DNA-ICM) in diagnosis of lung cancer.Methods 532 cases of bronchoalveolar lavage fluid (BALF) and (or) bronchial brushing cytology (216 cases from lung cancer patients and 209 cases from benign lung disease patients) were detected by DNA-ICM and liquid-based cytology (LBC), respectively.The sensitivity and specificity of the two methods were compared.Results The sensitivity and specificity of DNA-ICM were 69.2%and 100.0%, and which of LBC were 46.7% and 97.9%, respectively.The sensitivity of DNA-ICM was significantly higher than that of LBC method in the diagnosis of lung cancer (P<0.05).The sensitivity and specificity of DNA-ICM of BALF were 71.9% and 100.0%, while those of LBC were 48.2% and 98.5%.The sensitivity and specificity of DNA-ICM of bronchial brushing cytology were 62.8% and 100.0%, while those of LBC were 43.0% and 95.3%.The sensitivity of DNA-ICM of BALF and bronchial brushing cytology were higher than that of LBC method ( P<0.05).There were 107 patients who underwent BALF and bronchial brushing cytology simultaneously, the sensitivity of DNA-ICM of BALF was higher than that of bronchial brushing cytology ( P <0.05).Among different histologic types of the lung cancers, the sensitivity of squamous carcinoma was higher that of adenocarcinoma.Conclusions DNA-ICM has great application value in the diagnosis of lung cancer.DNA-ICM in combination with LBC can increase the detection rate of lung cancer. DNA-ICM of BALF is worthy of application in clinical practice.
