Value of CK5/6, CK14, ER and PR detection in differential diagnosis of intraductal proliferative lesions of the breast
10.3760/cma.j.issn.0253-3766.2015.10.007
- VernacularTitle:CK 5／6 CK 14雌激素受体和孕激素受体检测在乳腺导管内增生性病变辅助诊断中的应用
- Author:
Fengting NIU
1
;
Li WANG
;
Wei ZHANG
;
Shuhua LYU
;
Yun NIU
Author Information
1. 300060天津医科大学肿瘤医院乳腺病理科国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室 乳腺癌防治教育部重点实验室
- Keywords:
Breast neoplasms;
Usual ductal hyperplasia;
Atypical ductal hyperplasia;
Low-grade ductal carcinoma in situ;
CK5/6;
CK14;
Estrogen receptor;
Progesterone receptor
- From:
Chinese Journal of Oncology
2015;(10):749-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of high?molecular?weight keratins CK5/6, CK14, estrogen receptor ( ER) and progesterone receptor ( PR) in differential diagnosis of simple ductal hyperplasia ( UDH) , atypical ductal hyperplasia ( ADH) and low?grade ductal carcinoma in situ ( low?grade DCIS) . Methods The clinicopathological data of twenty cases of atypical ductal epithelial hyperplasia ( ADH) with focal cancerization changed into low?grade DCIS diagnosed at Tianjin Medical University Cancer Institute and Hospital between January 2013 and February 2014 were reviewed and analyzed. The expressions of CK5/6, CK14, ER and PR were detected by immunohistochemistry. Results Positive expressions of CK5/6 and CK14 were seen in UDH showing a mosaic pattern, while negative expression in ADH and low?grade DCIS. In addition, CK5/6 and CK14 were positively expressed in the myoepithelial cells of UDH, ADH and low?grade DCIS. Positive expressions of ER and PR were observed in UDH, ADH and low?grade DCIS. But they presented diffuse and homogeneous strong positive expression in ADH and variable positive expression in UDH. Conclusion In the intraductal proliferative lesions of the breast, the use of combined detection of the expression of CK5/6, CK14, ER and PR is of practical significance in the differential diagnosis of UDH, ADH and low?grade DCIS.
