Preliminary study on the changes of residual lipoprotein-cholesterol after three meals in patients with coronary heart disease
10.7619/jcmp.201907003
- VernacularTitle:冠心病患者三餐后残粒脂蛋白-胆固醇变化的初步研究
- Author:
Yuanyuan XIAO
1
;
Mengling HOU
;
Shenghu HE
Author Information
1. 扬州大学临床医学院 江苏省苏北人民医院
- Keywords:
residual lipoprotein-cholesterol;
postprandial;
coronary heart disease;
serum total cholesterol;
low-density lipoprotein cholesterol;
high-density lipoprotein cholesterol;
triglycerides
- From:
Journal of Clinical Medicine in Practice
2019;23(7):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of residual lipoprotein-cholesterol (RLP-C) after three meals in coronary heart disease group and control group, to explore the best time point for detecting post-prandial RLP-C levels. Methods Thirty-one patients andcontrols were recruited and divided into coronary heart disease group and control group. Vein blood samples were collected at 4 hours of fasting and three meals, and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) concentrations were measured. Serum RLP-C levels was calculated according to the equation. Results There were no significant differences in serum fasting TC, TG, LDL-C, non-HDL-C and RLP-C levels between CHD patients and controls (P＞ 0. 05). The CHD patients had lower HDL-C concentrations than controls (P ＜ 0. 05). Postprandial serum TG and RLP-C levels increased significantly in CHD patients after each meal (P ＜ 0. 01), and reached the peak at 4 hours after dinner. The CHD patients had higher postprandial serum RLP-C levels after lunch and dinner, and higher serum TG level after lunch than the controls (P ＜ 0. 05). Conclusion There was no significant difference in the concentration of fasting serum RLP-C between the two groups. However, its concentration changed more significantly at 4 hours after lunch and dinner compared to that of fasting. Therefore, the RLP-C level measured at 4 hours after lunch and dinner may be more practical in clinic.
