Effect of preoperative transcatheter arterial chemoembolization on the perioperative outcome of patients with hepatocellular carcinoma
10.3760/cma.j.issn.0253-3766.2015.09.009
- VernacularTitle:术前介入治疗对肝细胞癌患者围手术期转归的影响
- Author:
Weiqi RONG
1
;
Weibo YU
;
Fan WU
;
Jianxiong WU
;
Liming WANG
;
Fei TIAN
;
Songlin AN
;
Li FENG
;
Faqiang LIU
Author Information
1. 100021中国医学科学院北京协和医学院肿瘤医院腹部外科
- Keywords:
Carcinoma,hepatocellular;
Hepatectomy;
Transcatheter arterial chemoembolization,TACE;
Liver function
- From:
Chinese Journal of Oncology
2015;(9):671-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the surgical risk, perioperative outcome and the response of patients with hepatocellular carcinoma ( HCC ) after preoperative transcatheter arterial chemoembolization ( TACE) . Methods A retrospective case?matched study was conducted to compare the characteristics and corresponding measures of patients in the preoperative TACE group and the control group without TACE. A total of 105 patients ( 82 patients with selective and dynamic region?specific vascular occlusion to perform hepatectomy for patients with complex hepatocellular carcinoma) was included in this study, in which 35 patients underwent TACE therapy, and a 1 ∶ 2 matched control group of 70 subjects. Results The patients of preoperative TACE therapy group had a higher level of γ?glutamyl transpeptidase before operation (119.52± 98.83)U/L vs. (67.39±61.25) U/L (P=0.040). The operation time was longer in the TACE group than that in the control group but with a non?significant difference (232.60±95.43) min vs. (218.70±75.13) min ( P=0.052) . The postoperative recovery of liver function and severe complications in the preoperative TACE group were similar to that in the control group ( P>0.05) . There were no massive hemorrhage, biliary fistula and 30?d death neither in the treatment group and matched control group. Conclusions Preoperative TACE therapy has certain negative effect on liver function. It is preferable to use selective and dynamic region?specific vascular occlusion technique during hepatectomy and combine with reasonable perioperative treatment for this group of patients, that can ensure safety of patients and promote their rapid recovery.
