Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine
10.14148/j.issn.1672-0482.2024.0503
- VernacularTitle:中药挥发油透皮促渗苷类成分效果与经皮水分散失量的相关性研究
- Author:
Senlan HUANG
1
,
2
;
Xixi ZHU
;
Shanshan LU
;
Zhichao SONG
;
Jie DONG
;
Yiwei WANG
;
Jun CHEN
Author Information
1. 南京中医药大学药学院,江苏 南京 210023
2. 南京中医药大学江苏省中医外用药开发与应用工程研究中心,江苏 南京 210023
- Keywords:
essential oils from traditional Chinese medicine;
transepidermal penetration enhancers;
transepidermal water loss;
skin barrier function;
correlation analysis
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2024;40(5):503-509
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the correlation between penetration enhancement effect and transepidermal water loss(TEWL)values of essential oils(EOs)from traditional Chinese medicine(TCM).METHODS The amount of 3 kinds of glycosides(geniposide,gentiopicroside,paeoniflorin)and their oil-water partition coefficient were determined by HPLC.The penetration enhancement effect of the five EOs from Gaoliangjiang(Alpiniae Officinarum Rhizoma,AOR),Ganjiang(Zingiberis Rhizoma,ZR),Bohe(Menthae Haploca-lycis Herba,MHH),Hujiao(Piperis Fructus,PF)and Wuzhuyu(Euodiae Fructus,EF)on geniposide,gentiopicroside,and paeoniflor-in were performed by the modified Franz diffusion cell method with the abdominal skin of rats.The TEWL values were measured to evalu-ate the effect of the five EOs on the skin barrier function of rats.The correlation between penetration enhancement effect of EOs and their effect on skin barrier function was investigated by correlation analysis.RESULTS AOR oil,ZR oil,MHH oil,and PF oil could im-prove the absorption of the three glycosides and reduce skin barrier function of rats.The results of correlation analysis showed that the penetration enhancement effect of EOs was significantly related to TEWL values following dermal administration of EOs.CONCLUSION TEWL measurement technology provides a more convenient method for the selection of penetration enhancers.
