Clinical Study on the Treatment of Advanced Liver Cancer of Qi Deficiency and Toxic Stasis Type by Jiawei Yupingfeng San
10.14148/j.issn.1672-0482.2024.0413
- VernacularTitle:加味玉屏风散治疗气虚毒瘀型晚期肝癌的临床研究
- Author:
Zongao WANG
1
;
Minghui ZHANG
;
Hua SUN
;
Yiran OUYANG
;
Lanmei ZHAO
;
Ting ZHANG
;
Fei YAO
;
Qin YUAN
;
Guorong JIANG
;
Lurong ZHANG
;
Min LIU
Author Information
1. 南京中医药大学附属苏州市中医医院,江苏 苏州 215009
- Keywords:
advanced liver cancer;
thymic stromal lymphopoietin(TSLP);
Jiawei Yupingfeng San;
Yupingfeng San;
quality of survival;
tumor growth;
qi deficiency and toxic stasis
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2024;40(4):413-418
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the clinical efficacy and effect on serum thymic stromal lymphopoietin(TSLP)levels of pa-tients with advanced liver cancer of qi deficiency and toxic stasis type by Jiawei Yupingfeng San.METHODS Using random double blind method,120 patients with advanced liver cancer of qi deficiency and toxic stasis type were randomly divided into 3 groups:Jiawei Yupingfeng San group,Yupingfeng San group,and placebo group,each consisting of 40 cases.All patients in the 3 groups were given conventional treatment such as radiotherapy,chemotherapy,interventional or targeted therapy;Jiawei Yupingfeng San group was given Jiawei Yupingfeng San granules,Yupingfeng San group was given Yupingfeng San granules,and placebo group was given placebo.The course of treatment was 2 months.The changes of Karnofsky functional status score(KPS score),TCM syndrome score,tumor size and serum TSLP level in the 3 groups were observed before and after treatment,and the correlation between the changes of tumor size and TSLP was analyzed.RESULTS After treatment,the KPS scores of Yupingfeng San group and Jiawei Yupingfeng San group were sig-nificantly increased(P<0.05,P<0.01),TCM syndrome score were decreased(P<0.01),tumor growth(P<0.05,P<0.01)was de-layed,and serum TSLP levels(P<0.05,P<0.01)were decreased.Furthermore,there was a slight positive correlation between chan-ges in tumor size and changes in TSLP(P<0.05).In terms of improving tumor size,the curative effect of Jiawei Yupingfeng San group was better than that of Yupingfeng San group(P<0.05).During the treatment period,no obvious adverse reactions were observed in the 3 groups of patients.CONCLUSION Combined with conventional treatment,Jiawei Yupingfeng San can significantly delay tumor growth in patients with advanced liver cancer of qi deficiency and toxic stasis type and improve patients'TCM syndromes and their qual-ity of survival.The therapeutic mechanism is related to reducing the expression of serum TSLP and improving the immune status of pa-tients,thereby delaying the growth of tumors.
