Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer
10.3760/cma.j.issn.0253-3766.2015.07.007
- VernacularTitle:极光激酶A p53及p21 WAF1协同表达在非小细胞肺癌预后中的价值
- Author:
Xue LI
1
;
Ningbo LIU
;
Peng REN
;
Qinchen CAO
;
Peng WANG
;
Lujun ZHAO
;
Bo LU
;
Ping WANG
Author Information
1. 300060,天津医科大学肿瘤医院放疗科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室
- Keywords:
Carcinoma,non-small-cell lung;
Prognosis;
Immunohistochemistry;
Aurora kinase A;
Ki-67 antigen;
p53;
Cyclin-dependent kinase inhibitor p21 WAF1
- From:
Chinese Journal of Oncology
2015;(7):512-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the prognostic value of combined expression of Aurora A, Ki?67, p53 and p21 WAF1 in patients after curative resection of non?small cell lung cancer(NSCLC). Methods Expressions of Aurora A, Ki?67, p53 and p21 WAF1 in 58 tumor samples from resected primary NSCLCs were detected by immunohistochemistry. The correlation of proteins, survival and clinicopathological characteristics was analyzed. Results The positive rates of Aurora A, Ki?67, p53 and p21 WAF1 expression were 89.7% (52/58), 53.4% (31/58), 46.6% (27/58) and 34.5% (20/58), respectively. Aurora A expression was positively correlated with nodal metastasis(69.2% vs. 37.8% , P=0.045). The univariable analysis showed that the overall survival ( OS) was 75. 0%in patients with low Aurora A expression and 46.0% in patients with high Aurora A expression ( P=0.039) . The 3?year survival rate was 40.0% in patients with positive expression of Aurora A and p53, 65.0% in the patients with positive expression of Aurora A or p53, and 82. 1% in the patients with negative expression of Aurora A and p53 ( P=0. 039 ) . The Cox regression model showed that combined expression of Aurora and p53 is an independent factor affecting the prognosis of NSCLC patients ( P=0. 015 ) . Conclusions Our findings suggest that the positive expression of Aurora A, Ki?67 and p53 proteins is an unfavorable factor affecting the prognosis for NSCLC patients, and the overexpression of Aurora A is an independent unfavorable factor association with shorter OS in NSCLC patients. Detection of positive Aurora A and p53 expression may be a useful predictive prognostic indicator for NSCLC patients.
