Genetic variation in SDC2 is associated with the risk of radiation esophagitis in patients with esophageal squamous cell carcinoma receiving radiotherapy
10.3760/cma.j.issn.0253-3766.2015.06.005
- VernacularTitle:硫酸类肝素蛋白多糖基因遗传变异与食管鳞癌放疗患者放射性食管炎发生风险的相关性
- Author:
Meng ZHANG
1
;
Wencheng ZHANG
;
Meng Zhang DU
;
Wencheng ZHANG
;
Zhongli DU
;
Hongmin LI
;
Ying HUANG
;
Dianke YU
;
Lijun TAN
;
Dongxin LIN
;
Zefen XIAO
;
Wen TAN
Author Information
1. 100021,北京协和医学院 中国医学科学院肿瘤医院病因及癌变研究室 癌发生及预防分子机理北京市重点实验室
- Keywords:
Subject words] Esophageal neoplasms;
Polymorphism,single nucleotide;
SDC2;
Radiotherapy;
Radiation esophagitis
- From:
Chinese Journal of Oncology
2015;(6):422-426
- CountryChina
- Language:Chinese
-
Abstract:
model. Results The median survival time (MST) of these patients was 14 months. Of them, 260 (87.8%) had died until the last date of follow?up of 30 June, 2014. Clinical stage ( stage Ⅳ vs. stage Ⅱ) and total radiation dose (≥ 60 Gy vs. <60 Gy) influence the overall survival time of the patient significantly. Cox proportional hazards regression model analysis showed that the subjects with rs61599409 T allele had an decreased hazard ratio as compared with those with C allele ( adjusted HR=0.82, 95% CI, 0.66?1.02) , but the difference was not statistically significant ( P=0.071) . The rest 10 htSNPs were not associated with the overall survival of ESCC patients treated with radiotherapy. Among this set of patients, 160 ( 54. 1%) suffered from radiation esophagitis. We found that rs17788084 A > T SNP in the 3′?untranslational region of SDC2 was associated with esophagitis risk, with the OR being 0.48 (95% CI=0.28?0.85, P=0.011) for the TA or TT genotype compared with the AA genotype. Conclusions These results suggest that rs17788084 genetic variation in SDC2 is associated with risk of radiation esophagitis and might serve as a potential biomarker for personalized radiotherapy of ESCC.
