Effect of compound danshen dropping pills, aspirin enteric-coated tablets combined with low-dose estrogen on treatment of patients with thin endometrium
10.7619/jcmp.201811027
- VernacularTitle:复方丹参滴丸、阿司匹林肠溶片联合小剂量雌激素治疗薄型子宫内膜的临床疗效观察
- Author:
Minyan YANG
1
;
Guanyou HUANG
;
Shuyun ZHAO
;
Jun WANG
;
Yan YUAN
;
Shixiang LI
Author Information
1. 贵州医科大学附属医院生殖中心
- Keywords:
compound danshen dropping pills;
aspirin enteric-coated tablets;
estrogen;
thin endometrium;
pregnancy rate
- From:
Journal of Clinical Medicine in Practice
2018;22(11):98-100,103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical effect of compound danshen dropping pills,aspirin enteric-coated tablets combined with small dose of estrogen on treatment of patients with thin endometrium.Methods A total of 69 patients with thin endometrium were collected and divided into 3 groups.Group Ⅰ was treated with estrogen at 3 to 5 days after menstrual period,group Ⅱ was treated with aspirin and compound danshen dropping pills,and group Ⅲ was treated with estrogen,aspirin and compound danshen dropping pills.General condition,ovulation,drug use,endometrial growth before and after the use of drugs and pregnancy rate were compared.Results There were no significant differences in general situations and ovulation results before treatment among three groups (P ＞0.05).After medication,the endometrial thickness of the 3 groups improved significantly,and the endometrial thickness of group Ⅲ was significantly better than group Ⅰ and Ⅱ (P =0.005,0.012).In group Ⅰ,Ⅱ and Ⅲ,the proportion of endometrium more than 7 mm after treatment was 38.1％,16.7％ and 60％ respectively,and the success rate of group Ⅲwas significantly higher than that of group Ⅰ and Ⅱ (P =0.008).The clinical pregnancy rate in group Ⅲ was significantly higher than that in group Ⅰ and Ⅱ (P =0.049).Conclusion Compound danshen dropping pills,aspirin entericcoated metformin combined with small dose of estrogen can significantly improve endometrium and pregnancy rate in patients with thin endometrium,with less estrogen dosage.
