Analysis of clinicopta hological features and prognosis between alpha-fetopor tein negatvi e and positive hepaot cellular carcinoma pa tients atf er R0 radical hepatectomy
10.3760/cma.j.issn.0253-3766.2015.04.014
- VernacularTitle:甲胎蛋白阴性和甲胎蛋白阳性肝细胞癌临床病理特征及 R0切除后生存分析
- Author:
Songlin AN
1
;
Weiqi RONG
;
Liming WANG
;
Fan WU
;
Weibo YU
;
Li FENG
;
Faqiang LIU
;
Fei TIAN
;
Chao BI
;
Jianxiong WU
Author Information
1. 100021,北京协和医学院 中国医学科学院肿瘤医院腹部外科
- Keywords:
Carcinoma,hepatocellular;
Hepatectomy;
Alpha-fetoprotein;
Prognosis
- From:
Chinese Journal of Oncology
2015;(4):308-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences between clinicopathological features and prognosis of alpha-fetoprotein ( AFP ) negative ( AFP<20 ng/ml ) and positive ( AFP≥20 ng/ml ) hepatocellular carcinoma ( HCC) patients.Methods Clinicopathological data of 142 AFP-negative and 109 AFP-positive HCC patients who underwent R0 radical hepatectomy in the Cancer Hospital of Chinese Academy of Medical Sciences between January 2006 and December 2011 were retrospectively reviewed and analyzed in this study.Results Compared with the AFP-negative patients, a higher female to male sex ratio, the later Barcelona Clinic Liver Cancer ( BCLC ) stage, more liver capsule invasion and poorer Edmondson-Steiner grade were in the AFP-positive cases (P<0.05 for all).Furthermore, the 1-, 3-, and 5-year overall survival rates were 94.4%, 82.4%and 61.0%in the AFP-negative group and 87.2%, 61.1%and 40.2%, respectively, in the AFP-positive group ( P<0.001 ) .The multivariate analysis with Cox′s proportional hazards model showed that AFP status, tumor size and Edmondson-Steiner grade are independent risk factors for survival of all the patients ( P<0.05) , and large tumor and Edmondson-Steiner gradesⅢ/Ⅳare independent risk factors for worse survival in AFP-negative patients ( P<0.05) .However, large tumor diameter was proved to be an independent risk factor leading to poor prognosis of AFP-positive cases (P<0.05).Conclusion High levels of AFP indicate that the tumors are more malignant and with unfavorable prognosis.
