Study on the Effect of Moslae Herba Oil on the Percutaneous Absorption of Active Ingredient of Evodia Rutaecarpa in vitro
10.14148/j.issn.1672-0482.2024.0026
- VernacularTitle:香薷挥发油对吴茱萸有效成分透皮吸收的影响
- Author:
Qiujuan LI
1
;
Yafang LIANG
;
Juan SHU
;
Congling JIA
;
Chanchan LIU
;
Qinan WU
Author Information
1. 南京中医药大学药学院,江苏 南京 210023
- Keywords:
Moslae herba oil;
Evodia rutaecarpa;
penetration enhancers
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2024;40(1):26-36
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate whether Moslae herba oil has penetration enhancing effect on the active components of Evodia rutaecarpa and its ability to promote transdermal absorption.METHODS In vitro transdermal experiments were performed u-sing the diffusion pool and the isolated skin of rats.Using various components of Evodia rutaecarpa as indicators,HPLC was deter-mined to calculate the umulative penetration amount of each component.Changes in the skin and cuticle layers were observed by HE staining,immunohistochemical staining,and ATR-FTIR.GC-MS was used to measure Moslae herba oil components after administration.RESULTS Moslae herba oil showed the penetration-enhancing effect on various components in Evodia rutaecarpa.Compared with the postive drug nitrogenone,the cumulative penetration amounts of hyperoside,evodiamine and rutae-carpine were greater.In addition,the sesquiterpene composition and thymol in the Moslae herba oil were more likely to be stored in the skin,which could disturb the lipid structure of the cuticle layer and promote the penetration of drugs.CONCLUSION The results provide reference for the selection of transdermal absorption agent.
