Clinicopathologic features and prognosis of 51 patients withα-fetoprotein-producing gastric cancer
10.3760/cma.j.issn.0253-3766.2015.03.017
- VernacularTitle:51例产甲胎蛋白胃癌的临床病理特征和预后
- Author:
Xiaoling LIU
1
;
Mudan YANG
;
Jun GAO
;
Suzhen ZHANG
;
Yanfeng XI
Author Information
1. 山西省肿瘤医院消化二科
- Keywords:
Stamochneoplasms;
α-fetoprotein,AFP;
Immunohistochemistry;
Prognosis
- From:
Chinese Journal of Oncology
2015;(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinicopathologic features and prognosis of α-fetoprotein ( AFP)-producing gastric cancers ( AFPGC) .Methods Fifty-one serum AFP-positive patients with positive immunohistochemical staining of AFP in the primary lesions ( study group) and sixty-five gastric cancer cases with normal AFP level ( control group) treated in our department from January 2005 to December 2007 were included in this study.Their clinicopathologic features and follow-up data were statistically analyzed. Results Compared with the control group, the study group had a higher incidence of poorly differentiated adenocarcinoma (P=0.021) and liver metastasis (P=0.001) than that in the control group.The TNM stages in the study group were significantly higher than those in the control group (P=0.001).The 1-, 2-, and 5-year survival rates of the study group were 62.7%, 27.5%and 4.7%, respectively, and the median survival was 16 months, significantly lower than the 84.6%, 55.4%, 16.5%, and 30 months of the control group (P<0.001 for all).The serum AFP levels in the study group ranged from 58.63μg/L to 12 100.00μg/L, and could be classified into two groups:27 cases <500μg/L, and 24 cases≥500μg/L.There was no significant difference of the immunohistochemical staining results between the two subgroups ( P =0.912) .Conclusions AFPGC is a special type of gastric cancer with high degree of malignancy and poor prognosis.Monitoring of serum AFP level can earlier detect the progression of disease and give corresponding treatment.
