Research Progress of Chinese Medicine in Regulating Autophagy-Related Pathways Against Lung Cancer
10.14148/j.issn.1672-0482.2023.1155
- VernacularTitle:中药调控自噬相关通路抗肺癌的研究进展
- Author:
Cheng LUO
1
;
Yuan-Hang YE
;
Jin-Wen TU
;
Jia KE
Author Information
1. 湖北中医药大学中医学院,湖北 武汉 430060
- Keywords:
traditional Chinese medicine;
autophagy;
signaling pathway;
lung cancer
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2023;39(11):1155-1164
- CountryChina
- Language:Chinese
-
Abstract:
As a malignant tumor with high incidence and mortality worldwide,lung cancer seriously threatens the life and health of human beings.At present,clinical treatment of lung cancer is mainly based on surgery combined with radiotherapy and chemotherapy and other comprehensive treatments,which can control the progression of lung cancer to a certain extent,but there are still problems such as low survival rate and poor quality of life.Autophagy is a complex intracellular self degradation mechanism.The occurrence of autophagy is closely related to autophagy-related gene proteins and signal pathways.Research shows that reasonable regulation of signal pathway can interfere with autophagy leading to lung cancer cell death and inhibit tumor growth.In recent years,the regulation of auto-phagy-related signaling pathways in Chinese medicine against lung cancer has become a hot spot in the field of oncology research.Therefore,this paper compares and summarizes the research on the regulation of autophagy-related signaling pathways in Chinese medicine against lung cancer in recent years,in order to provide a reference basis for the development of new drugs and clini-cal application of Chinese medicine against lung cancer.
