Clinical Study of Modified Chaihu Guizhi Decoction in Treating Stable Angina Pectoris of Coronary Heart Disease with Anxi-ety/Depression of Qi Stagnation and Blood Stasis Type
10.14148/j.issn.1672-0482.2023.1122
- VernacularTitle:加味柴胡桂枝汤治疗气滞血瘀型冠心病稳定性心绞痛伴焦虑/抑郁的临床研究
- Author:
Hai-Quan HUANGFU
1
;
Hui-Chun HUANG
;
Hai-Rui YU
;
Xiao-Ming SHANG
;
Wei-Qian LIAO
Author Information
1. 上海中医药大学深圳医院/深圳市罗湖区中医院,广东 深圳 518000
- Keywords:
modified Chaihu Guizhi Decoction;
stable angina pectoris of coronary heart disease;
anxiety and depression;
qi stagna-tion and blood stasis type
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2023;39(11):1122-1128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the clinical efficacy of modified Chaihu Guizhi Decoction in treating stable angina pectoris with anxiety/depression in patients with coronary heart disease of qi stagnation and blood stasis type.METHODS 60 patients with stable angina pectoris and anxiety/depression caused by qi stagnation and blood stasis type of coronary heart disease were included in the study.They were randomly divided into a control group(n=30)and a treatment group(n=30).Both groups of patients received health education,psychological counseling,and routine treatment for coronary heart disease angina pectoris.The control group received droperidol melitracin tablets in addition to basic treatment,while the treatment group received modified Chaihu Guizhi Decoction in ad-dition to basic treatment for 4 weeks.The efficacy of traditional Chinese medicine(TCM)syndrome,total score of traditional Chinese medicine syndrome,angina symptom score,electrocardiogram treadmill exercise test,nitroglycerin withdrawal rate,self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Seattle angina questionnaire(SAQ)scores between the two groups of patients were compared before and after treatment.At the same time,peripheral blood lipids and IL-6 levels were measured.RESULTS Af-ter treatment,the TCM syndrome score,angina symptom score,SAS,SDS score of both groups of patients decreased(P<0.01),and the scores of various dimensions of SAQ increased(P<0.01).The occurrence time of ST segment depression of 1mm in treadmill exer-cise test was prolonged,the occurrence time of angina was prolonged,and the recovery time of ST segment was shortened(P<0.01),and TC,TG,LDL-C,IL-6 were significantly reduced(P<0.05,P<0.01).Moreover,the treatment group was superior to the con-trol group in improving TCM syndrome scores,angina symptom scores,SAS,SDS scores,PL and TS scores in SAQ,apparent effective rate of TCM syndrome,nitroglycerin cessation rate,blood lipids(TC,LDL-C),and serum IL-6(P<0.05,P<0.01).CONCLU-SION Modified Chaihu Guizhi Decoction can significantly improve the clinical symptoms,anxiety and depression status of patients with stable angina pectoris and anxiety/depression of qi stagnation and blood stasis type of coronary heart disease,improve quality of life,reduce blood lipids and IL-6 levels.
