Value of 18 F-FDG PET in preoperative TACE of hepatocellular carcinoma
10.3760/cma.j.issn.0253-3766.2014.05.012
- VernacularTitle:18 F-脱氧葡萄糖正电子发射计算机体层摄影在肝动脉化疗栓塞术治疗原发性肝癌患者预后判断中的价值
- Author:
Zhongfei CHANG
1
,
2
;
Peng SONG
;
Maoqiang WANG
;
Fengyong LIU
;
Feng DUAN
;
Zhijun WANG
;
Yan WANG
Author Information
1. 100853 北京，解放军总医院介入放射科
2. 100043 首都医科大学石景山教学医院北京市石景山医院肿瘤科
- Keywords:
Liver neoplasms;
Transarterial chemoembolization;
Positron-emission tomography;
Prognosis
- From:
Chinese Journal of Oncology
2014;(5):377-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic significance of 18 F-FDG PET-CT SUVmax value in 85 patients with hepatocellular carcinoma ( HCC ) before transarterial chemoembolization ( TACE ) . Methods A retrospective analysis was conducted on 85 patients with HCC before TACE to evaluate the prognostic significance of SUVmax of 18 F-FDG PET-CT.The survival rates were calculated using Kaplan-Meier method.Log-rank method was used for univariate analysis , and Cox regression model was used for multivariate analysis .Results The patients were divided into two groups before TACE:The high metabolic group (63 patients, with SUVmax value 7.71 ±2.78) and low metabolic group (22 patients, with SUVmax value 3.89 ±0.80).The SUVmax levels were statistically different ( P<0.001).The 1-, 2-and 3-year survival rates of the 63 patients of high metabolic group were 66.6%, 26.9% and 12.6%, respectively. The 1-, 2-and 3-year survival rates of the 22 patients of low metabolic group were 81.8%、72.7% and 63.6%, respectively.The median survival time of the high metabolic group was 16.0 months and that of the low metabolic group was 48.0 months (P=0.001).Univariate analysis indicated that SUVmax value of the intrahepatic primary tumor, hepatic cirrhosis, Child-Pugh score, ECOG score, intrahepatic tumor size, number of tumors(solitary or multiple), portal vein tumor thrombus,BCLC stage, and serum AFP level were significantly correlated with prognosis of the patients (P<0.05 for all).Multivariate analysis indicated that SUVmax value , tumor size >8 cm, number of tumors ( solitary or multiple ) and AFP level were independent prognostic factors ( P <0.05 for all ).Conclusion The SUVmax value of the primary intrahepatic tumor can be used as an important prognostic factor to predict the effect of TACE in patients with hepatocellular carcinoma .
