Expression characteristics and diagnostic value of serum collagen, carcinoembryonic antigen and antigen 199 in esophageal cancer
10.7619/jcmp.201809013
- VernacularTitle:血清骨胶素、癌胚抗原、抗原199在食管癌中的表达特点及诊断价值
- Author:
Chunyan HE
1
;
Yingying SHI
;
Jing DENG
;
Weian WANG
Author Information
1. 武警总医院消化科
- Keywords:
serum collagen;
carcino-embryonic antigen;
antigen 199;
esophageal cancer
- From:
Journal of Clinical Medicine in Practice
2018;22(9):51-53,57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significance of CYFRA 21-1,CEA and CA199 in patients with esophageal cancer.Methods patients with esophageal cancer (esophageal cancer group) and 90 healthy subjects (control group) were enrolled in this study.Serum levels of CYFRA 21-1,CEA,and CA 199 were measured in two groups.Patients with esophageal cancer were subdivided according to TNM stage,differentiation,and lymph node metastasis condition,and the diagnostic value was calculated.Results The serum levels of CYFRA 21-1,CEA and CA 199 in patients with esophageal cancer were significantly higher than that in the control group (P ＜ 0.05).The levels of above indicators in esophageal cancer patients with poorly differentiation,lymphatic metastasis in Ⅲ and Ⅳ stages were significantly higher than those in Ⅰ,Ⅱ phase of TNM staging,high and mild differentiation,and without lymph node metastasis (P ＜ 0.05).The sensitivity and specificity,missed diagnosis rate,misdiagnosis rate of combined detection of CYFRA 21-1,CEA,CA 199 levels for esophageal cancer were 80.00％,94.44％,20.00％,5.56％,respectively.Conclusion The levels of CYFRA 21-1,CEA,CA 199 in patients with esophageal cancer serum are significantly increased,and the combination detection of above three indicators has significant diagnosis value.
