Expression and function of HIF and its target genes BNIP3, VEGF in gastric adenocarcinoma
10.3321/j.issn:0253-3766.2008.01.011
- VernacularTitle:缺氧诱导因子及其应答基因BNIP3和血管内皮生长因子在胃腺癌中表达及临床意义
- Author:
Neng-Lian LI
1
;
Xu ZHANG
;
Ya-Li WANG
Author Information
1. 甘肃中医学院
- Keywords:
Hypoxia inducible factor;
bcl-2/adenovirus E1B 19 000 interacting protein 3;
Vascular endothelial growth factor;
Stomach neoplasms;
Adenocarcinoma
- From:
Chinese Journal of Oncology
2008;30(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and mechanism of the hypoxia inducible factor (HIF) and their downstream responsive genes BNIP3, VEGF in gastric adenocarcinoma, and to investigate their clinical significance. Methods SP immunohistochemical method was used to detect the expression of HIF-1α, HIF-2α, BNIP 3 and VEGF in the tissue samples from 70 gastric adenocarcinoma patients. Results Compared with the normal tissue, gastric adenocarcinoma had significantly higher positive expression rate of HIF-1α(61.4% vs. 8.3%), HIF-2α(37.1% vs.0), BNIP3(51.4% vs.0) and VEGF(62.9% vs. 0). The expression of BNIP3 and VEGF was positively correlated with HIF-1α expression. The expressions of HIF-1α and VEGF was significantly and positively correlated with lymph node metastasis, while BNIP3 expression was negatively correlated with that. Conclusion Accumulation of hypoxia inducible factors regulate the expression and function of its downstream target genes, which may play a critical role in the carcinogenesis of gastric adenocarcinoma. VEGF expression is found to be related to poor biological behavior, but BNIP3 expression may suggest better prognosis of gastric adenocarcinoma.
