Effects comparison of salatrine or glimepiride combined with insulin glargine on treatment of patients with type 2 diabetes mellitus
10.7619/jcmp.201809008
- VernacularTitle:沙格列汀或格列美脲联合甘精胰岛素对2型糖尿病患者的疗效比较
- Author:
Zongling WANG
1
;
Lina DAI
;
Meixia WANG
;
Wen PAN
Author Information
1. 山东省青岛阜外心血管病医院内科
- Keywords:
sagatrine;
glimepiride;
insulin glargine;
type 2 diabetes;
blood glucose fluctuation;
oxidative stress
- From:
Journal of Clinical Medicine in Practice
2018;22(9):31-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of saxagliptin or glimepiride combined with insulin glargine on treatment of patients with type 2 diabetes mellitus.Methods Totally 86 patients with type 2 diabetes mellitus were selected and randomly divided into two groups.The control group was treated with glimepiride and insulin glargine,while the experiment group was treated with shagelline and insulin glargine.Before and after treatment,the blood glucose fluctuation index was measured by 72 h dynamic glucose test,and levels of FINS,2 hPG,HbA1c,MDA,ROS and SOD were measured.The clinical efficacy and safety indexes were compared.Results Compared with before treatment,the levels of SDBG,MAGE,NGE and MODD decreased significantly after treatment,the levels of FINS increased significantly,2 hPG and HbA1 c decreased significantly after treatment,and the levels of serum MDA and ROS decreased significantly and SOD level increased significantly (P ＜ 0.05).Compared with the control group,the levels of SDBG,MAGE,NGE and MODD were significantly lower in the experiment group,and the levels of MDA and ROS were significantly lower,and the level of SOD was significantly higher (P ＜ 0.05).The effective rate was 72.09％ in the control group,which was significantly lower than 90.70％ in the experiment group (P ＜ 0.05).Conclusion Compared with glimepiride,saxagliptin combined with insulin glargine is effective in the treatment of patients with type 2 diabetes,it can effectively control blood sugar,improve blood sugar fluctuations and oxidative stress,and does not increase the risk of hypoglycemia.
