Relationship between plasma TSP-1 and degree of coronary artery stenosis
10.7619/jcmp.201809002
- VernacularTitle:血浆血小板反应蛋白-1水平与冠状动脉狭窄病变程度的关系研究
- Author:
Jingwu WANG
1
;
Fengying AI
;
Dasheng WANG
;
You WU
;
Yanjie SU
;
Xinquan YANG
;
Daxin WANG
Author Information
1. 扬州大学临床医学院
- Keywords:
TSP-1;
atherosclerosis;
Gensini score;
coronary artery stenosis
- From:
Journal of Clinical Medicine in Practice
2018;22(9):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of of plasma TSP-1 level in patients with coronary atherosclerosis and its relationship with the degree of coronary artery stenosis and related plasma cytokines.Methods A total of 79 patients with chest pain were divided into low score group (n =27),medium score group (n =26),and high score group (n =26) according to Gensini score.Another 27 normal controls were included as control group.The levels of plasma TSP-1,hs-CRP,MMP-9 and TGF-β1 were detected by enzyme-linked immunoassay,and the relationship between TSP-1 and Gensini score,hs-CRP,MMP-9 and TGF-β1was analyzed.Results There were significant differences in level of plasma TSP-1 between four groups (P ＜ 0.05).The level of TSP-1 in plasma was correlated with hs-CRP (r =0.4979,P ＜ 0.001),MMP-9 (r =0.3940,P ＜ 0.001) and TGF-β1 (r =0.4889,P ＜ 0.001).The multiple stepwise linear regression analysis showed that there was a correlation between the degree of coronary artery stenosis and the plasma TSP-1 level.Conclusion Plasma TSP-1 level can be used as a biomarker for coronary stenosis.
