The Research Progress of Interaction Between Chinese and Western Medicine Combination
10.14148/j.issn.1672-0482.2018.0005
- VernacularTitle:中西药联用相互作用研究进展
- Author:
Xue-Yun KONG
1
;
Qi CHEN
;
Xiang WU
;
Hui-Min BIAN
;
Yu LI
Author Information
1. 南京中医药大学药学院
- Keywords:
combined use of Chinese medicine and western medicine;
pharmacokinetics;
drug enzyme;
efficacy;
adverse reaction
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2018;34(1):5-11
- CountryChina
- Language:Chinese
-
Abstract:
The compatibility of Chinese medicine and western medicine is becoming more and more common,but the changes in efficacy and adverse reactions of drug interaction caused by drug interaction has attracted more and more attentions.This article mainly expounds the interaction between Chinese medicine and western medicine in four aspects:absorption,distribution,metabolism and excretion of drugs.Among them,Chinese medicine can affect western medicine absorption by changing the gastrointestinal pH,gastrointestinal motility and gastric emptying time changes,the chelate complexes,and the precipitate formation;it can change the distribution of the main active ingredients in western medicine;it can change liver microsomal enzyme and non-microsomal enzyme to affect western medicine metabolism,the western medicine excretion through the bile and kidney,and western medicine transport process in vivo by P-glycoprotein.The article explains the pros and cons of Chinese medicine and western medicine from the pharmacokinetic process,which provides the basis for the clinical guidance for the combination therapy of Chinese medicine and western medicine.
