The Effects of Qingre Huoxue Yangyin Formula on Blood Lipid,Arterial Plaque and Th1/Th2 Imbalance in Atherosclerosis Model Rats
10.14148/j.issn.1672-0482.2017.0623
- VernacularTitle:清热活血养阴方对大鼠动脉粥样硬化模型血脂、动脉斑块及Th1/Th2失衡的影响
- Author:
Jing-Jing HE
1
;
Yun-Jing MA
;
Run-Ze QIU
;
Jun LONG
;
Shi-Hai YAN
;
Dong-Ping YUAN
;
Fu-Ming LIU
Author Information
1. 南京中医药大学附属医院
- Keywords:
Qingre Huoxue Yangyin Decoction;
atherosclerosis;
function unit;
Th1/Th2 imbalance
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(6):623-626
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the mechanism of intervention with atherosclerosis(AS)by Qingre Huoxue Yangyin Decoction and its functional units.METHODS The AS model of SD rats was successfully established with high fat diet and balloon injury.The model rats were randomly divided into model group,whole group,Huoxue group,Yangyin group,Qingre group and positive group,and received the intragastric administration,respectively.The blank group was fed with normal diet without medication.The changes of each group on blood lipid,arterial lesion and Th1/Th2-related cytokines were observed af-ter 4 weeks.RESULTS ①Compared to the model group,the whole decoction significantly reduced the plaque proportion and TG(P<0.05),increased HDL-C(P<0.05);reduced Th1-related cytokines TNF-αand INF-γ(P<0.05),increased Th2-re-lated cytokine IL-4(P<0.05).②Each function unit compared with the model group:Yangyin group obviously elevated IL-4 and decreased TG(P<0.05),Qingre group obviously decreased the IFN-γ,LDL-C and plaque proportion(P<0.05),Huox-ue group significantly reduced plaque ratio(P<0.01).CONCLUSION Qingre Yangyin Huoxue Decoction and each function u-nit can play a role in anti-atherogenesis by lowering blood lipids and regulating Th1 and Th2 subpopulations differentiation im-balance.
