Effect of Baicalin on Radiation-Induced Acute Lung Injury in Mice Through Antioxidant and Anti-Inflammatory Properties
10.14148/j.issn.1672-0482.2017.0613
- VernacularTitle:黄芩苷对辐射诱导的小鼠急性肺损伤保护作用机制研究
- Author:
Yong-Liang GE
1
;
Jin-Hua TAO
;
Mu-Jun WU
Author Information
1. 南通市通州区人民医院影像科
- Keywords:
baicalin;
radiation;
acute lung injury;
NF-κBp65
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(6):613-617
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE The current study was designed to evaluate the protective effects of baicalin on radiation-induced a-cute lung injury in mice.METHODS 50 ICR mice were divided into five groups randomly,namely,control group,X-ray group,X-ray+dexamethasone group(5 mg/kg),X-ray+baicalin group(20,40 mg/kg),with 8 in each group.Pathological changes in the lung tissues were observed.The ratio of lung wet/dry weight was also recorded.Besides,the level of neutrophil in bronchoalveolar lavage fluid(BALF)was detected to evaluate inflammatory cell infiltration.Moreover,the expressions of MDA,IL-6,TNF-α,p-NFκBp65 and p-IκBα,as well as the activity of SOD,were examined in lung.RESULTS Baicalin(20, 40 mg/kg)could effectively improve the radiation-induced lung pathological changes and reduce the number of inflammatory cells in BALF.The ratio of lung wet/dry weight was also decreased with the treatment of baicalin(20,40 mg/kg).In addi-tion,the activity of SOD was recovered and the end product of lipid peroxidation MDA was reduced meanwhile.The expres-sions of p-NFκBp65 and p-IκBαwas extensively down-regulated with baicalin(20,40 mg/kg)preconditioning,taking the ex-pressions of NFκBp65 and IκBαas inner controls.CONCLUSION Baicalin could alleviate radiation-induced acute lung injury due to its antioxidant and anti-inflammatory properties.
