Study on the Curative Effect of Qigui Yishen Decoction in the Treatment of Patients with Chronic Kidney Diseases of Spleen and Kidney Deficiency
10.14148/j.issn.1672-0482.2017.0570
- VernacularTitle:芪归益肾方治疗慢性肾脏病脾肾两虚证的临床研究
- Author:
Ming-Gang WEI
1
;
Wei-Ming HE
;
Feng-Ling LI
;
Ling ZHANG
;
Mei FEI
;
Pei-Hua XIONG
;
Wei SUN
Author Information
1. 苏州大学附属第一医院
- Keywords:
Qigui Yishen decoction;
chronic kidney disease;
deficiency syndrome of spleen and kidney;
clinical effect
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(6):570-573
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the clinical curative effect of Qigui Yishen decoction in the treatment of patients with chronic kidney diseases of spleen and kidney deficiency.METHODS Patients with chronic kidney diseases met the diagnosis criteria were divided into two groups.Both groups were given the high quality low protein,low salt,low fat,low phosphorus diet,and also given basic treatments such as correcting water and electrolyte disorders,acidosis,anemia,lowering blood pres-sure,anticoagulation and regulating lipid.On the basis of this,the treatment group was also given Qigui Yishen decoction o-rally.Objective indexes including kidney function,serum plasminogen activator inhibitor-1(PAI-1),transforming growth fac-tor-β1(TGF-β1)and changes of TCM syndrome scores were observed after four weeks.RESULTS After the treatment,TCM syndrome scores in two groups decreased significantly compared with pre-treatment(P<0.05~0.01),and the treatment group was better than the control group(P<0.05~0.01).PAI-1,ALB/Cr,TGF-β1 and IL-6 levels in two groups decreased significantly after treatment(P<0.05~0.01),and the treatment group was better the control group(P<0.05~0.01). CONCLUSIONS Qigui Yishen decoction has definite curative effect on protecting renal function and alleviating the progress of renal fibrosis,and its therapeutic effect may be related to the improvement of blood coagulation and endothelial cell function.
