Effect observation of clopidogrel combined with low molecular weight heparin on treating middle-aged and elderly patients with acute coronary syndrome
10.7619/jcmp.201807030
- VernacularTitle:氯吡格雷联合低分子肝素钠治疗中老年急性冠脉综合征的疗效观察
- Author:
Jianbo WANG
1
;
Rui HUANG
;
Zhenhua WANG
Author Information
1. 重庆市巫山县人民医院
- Keywords:
acute coronary syndrome;
low molecular weight heparin;
clopidogrel;
clinical efficacy
- From:
Journal of Clinical Medicine in Practice
2018;22(7):107-109,113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of clopidogrel combined with low molecular weight heparin on the treatment of middle-aged and elderly patients with acute coronary syndrome.Methods Totally 94 patients with acute coronary syndrome were selected and randomly divided into control group and observation group,47 cases in each group.The patients in the control group were given clopidogrel,while patients in the observation group were given clopidogrel combined with low molecular weight heparin sodium.The clinical efficacy,platelet aggregation rate,drug safety and cardiac function improvement were observed and compared between the two groups before and after treatment.Results The total effective rate in the observation group was 93.62％,which was significantly higher than 78.72％ in the control group (P ＜ 0.05).Mter the treatment for 1 and 2 weeks,the platelet aggregation rate in the observation group was significantly lower than that in the control group (P ＜ 0.05).After the treatment,LVEDD and LVESD levels in both groups were significantly lower than those before treatment,LEVF level was significantly higher than that before treatment,LVEDD and LVESD levels in the observation group were significantly lower than those in the control group,and LEVF level was significantly higher than the control group (P ＜ 0.05).There was no significant differences between the two groups in the incidence rates of bleeding,gastrointestinal reactions,headache and rash (P ＞ 0.05).Conclusion Clopidogrel combined with low molecular weight heparin is effective in the treatment of middle-aged and elderly patients with acute coronary syndrome,which can effectively reduce the platelet aggregation rate,enhance cardiac function and exercise tolerance,reduce the risk of sudden death and improve prognosis.
