Effect of ambrocol combined with montelukast sodium chewable tablets on the treatment of children with bronchiolitis and its influence on the immunology indexes
10.7619/jcmp.201807024
- VernacularTitle:氨溴特罗联合孟鲁司特钠咀嚼片治疗儿童毛细支气管炎的疗效及对免疫学指标的影响
- Author:
Danmeng SUN
1
Author Information
1. 神华神东总医院儿科
- Keywords:
ambrocol;
montelukast sodium chewable tablets;
children;
bronchiolitis;
immunology indexes
- From:
Journal of Clinical Medicine in Practice
2018;22(7):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ambrocol combined with montelukast sodium chewable tablets on the treatment of children with bronchiolitis and its influence on the indexes of immunology.Methods A total of 136 children with bronchiolitis were randomly divided into control group (n =68,treated with symptomatic therapy,inhaled corticosteroid and oral ambrocol therapy)and study group (n =68,treated with additional montelukast sodium chewable tablets on the basis of control group).The clinical efficacy,change of immunological indexes before and after treatment,disappearance time of clinical symptoms and signs,and adverse drug reactions were observed and compared between the two groups after one course of treatment.Results After one course of treatment,the total effective rate of study group was 97.06％,which was significantly higher than 86.76％ of control group (P ＜ 0.05).In study group,the levels of IgE,IL-10,IL-4 and ECP were significantly lower than the control group (P ＜ 0.05),while there was no significant difference of INF-γ between two groups (P ＜ 0.05).In the study group,the disappearance time of cough,fever disappeared time,disappearance time of asthma and disappeared time of lung dry rales were significantly shorter than the control group (P ＜ 0.05).No significant adverse reactions were observed between the two groups.Conclusion Ambrocol combined with montelukast sodium chewable tablets is effective in the treatment of children with bronchiolitis,which can enhance the clinical efficacy,shorten the course of disease and regulate the immunological indexes.
