Clinical Curative Effects Analysis of Self-made Yishen Jianpi Huayu Formula in the Treatment of Syndrome of Spleen and Kidney Yang Deficiency of Postmenopausal Osteoporosis
10.14148/j.issn.1672-0482.2017.0497
- VernacularTitle:自拟益肾健脾化瘀方治疗绝经后脾肾阳虚型骨质疏松症的临床研究
- Author:
Lin-Ling HUANG
1
;
Juan WU
;
Ying-Hui DENG
Author Information
1. 江西省妇幼保健院妇科
- Keywords:
self-made Yishen Jianpi Huayu formula;
postmenopausal osteoporosis;
clinical effect
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(5):497-500
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the Clinical curative effect of self-made Yishen Jianpi Huayu Formula in the treatment of syndrome of spleen and kidney yang deficiency of postmenopausal osteoporosis.METHODS From January 2016 to January 2017,120 postmenopausal osteoporosis patients included in our hospital were selected and randomly divided into the observa-tion group and the control group by random number,60 cases in each group.Both groups were given calcium carbonate D3 tab-lets.On the basis of this,the control group was given xianlinggubao capsules,and the observation group was given self-made Yishen Jianpi Huayu Formula.Both groups were treated for three months.RESULTS After treatment,the total clinical symptoms cores of lumbar and back pain,soreness and weakness of waist and knees,increasing of night urine,aversion to cold and cold limbs and lassitude in both groups were decreased significantly(P<0.01),but the observation group decreased more significantly(P<0.01).After treatment,the total effective rate in the observation group was 93.33％,which was significant-ly higher than that in the control group(80.00％,P<0.01).The bone mineral density of lumbar spine,L2～L4,femoral neck,greater trochanter of femur and Ward's pyramidal bone were significantly increased compared with pretreatment(P<0.01),but the observation group increased more significantly(P<0.01).Bone specific alkaline phosphatase(B-ALP)and tartrate resistant acid phosphatase(TRACP)in both group were decreased significantly(P<0.01)compared with pretreat-ment,but the observation group decreased more significantly(P<0.01).Estradiol(E2),insulin growth factor(IGF-1)in both group were increased significantly compared with pretreatment(P<0.01),and the observation group increased more sig-nificantly(P<0.01).The adverse events occurrence rates in both groups had no significant difference(P>0.05).CONCLU-SION Self-made Yishen Jianpi Huayu formula can significantly improve the clinical symptoms of postmenopausal osteoporo-sis,and improve patients'bone metabolism and bone mineral density at the same time.Its action mechanism may be associated with increased estrogen and IGF-1 levels.
