Correlation between chronic heart failure and vitamin D deficiency, parathyroid hormone level
10.7619/jcmp.201807006
- VernacularTitle:慢性心力衰竭与维生素D缺乏、甲状旁腺激素水平的相关性
- Author:
Walin YU
1
;
Jian BAI
;
Yanhan WANG
;
Nanjiao XU
;
Lian WANG
Author Information
1. 南京医科大学鼓楼临床医学院心血管内科
- Keywords:
heart failure;
vitamin D;
parathyroid hormone;
cardiac function;
ejection fraction
- From:
Journal of Clinical Medicine in Practice
2018;22(7):23-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between vitamin D,serum parathyroid hormone level and the severity of chronic heart failure.Methods Totally 97 heart failure patients with reduced left entricular ejection fraction were selected.The electrochemical luminescence test was used to detect level of 1,25 hydroxyvitamin D3,and chemiluminescence method was used to detect PTH level.Correlation between chronic heart failure and vitamin D deficiency,parathyroid hormone level.Results There were no significant differences in cardiac function between patients with different vitamin D levels.The correlation analysis showed that NYHA classification was negatively correlated with vitamin D (r =-0.210,P =0.039),positively correlated with PTH (r =0.356,P =0.000),and negatively correlated with VD/PTH (r =-0.388,P =0.000).The worse cardiac function indicated the higher PTH level and lower VD/PTH ratio,and there were significant differences (P ＜ 0.05).Vitamin D level decreased with the decrease of heart function.Conclusion In patients with HFrEF,the worse cardiac function may indicate the lower levels of vitamin D and VD/PTH as well as the higher PTH level.
