Study on Mechanism of Loganin Against AGEs Induced GMCs Injury via AGEs/RAGE/SphK1 Pathway

VernacularTitle:AGEs/RAGE/SphK1信号通路介导马钱苷抗AGEs损伤GMCs的机制研究
Author: Xing L(U) ¹ ; Hui-Qin XU ; Gao-Hong L(U) ; Yun-Hao WU ; Yu-Ping CHEN ; Hong-Sheng SHEN ; Guo-Ying DAI ; Kang XU
Author Information

1. 南京中医药大学药学院
Keywords: Cornus officinalis; loganin; advanced glycation end products; glomerulus mesangial cell; diabetic nephropathy
From: Journal of Nanjing University of Traditional Chinese Medicine 2017;33(4):382-385
CountryChina
Language:Chinese
Abstract: OBJECTIVE To study the mechanism of loganin,the effective componet of Cornus officinalis,on protecting the glomerulus mesangial cell (GMCs) injured by advanced glycation end products (AGEs).METHODS GMCs were divided into control,model (AGEs: 200mg/L),loganin (0.1,1,10μmol/L) groups.The cell proliferation,FN and COL-Ⅳ secretion,microstructure lesions,RAGE,SphK1,S1P and TGF-β protein expressions were measured.RESULTS AGEs induced cell proliferation,FN and COL-Ⅳ secretions,microstructure lesions,RAGE,SphK1,S1P and TGF-β protein expressions were suppressed by loganin.CONCLUSION Loganin can improve the AGEs induced GMCs injury by regulating the AGEs/RAGE/SphK1 signal pathway,and then ameliorate the diabetic nephropathy.