Acting Mechanism of Xiaofeng Xuanqiao Decoction for on Mice Model of Allergic Rhinitis
10.14148/j.issn.1672-0482.2017.0212
- VernacularTitle:消风宣窍汤对小鼠变应性鼻炎模型效应机制研究
- Author:
Jia-Lei TAO
1
;
Shou-Chuan WANG
;
Min-Cheng JIANG
;
Qi-Gang DAI
Author Information
1. 江苏省儿童呼吸疾病(中医药)重点实验室
- Keywords:
Xiaofeng Xuanqiao decoction;
allergic rhinitis;
mice;
thymus;
cytokine
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(2):212-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the therapeutic effects of Xiaofeng Xuanqiao Decoction in treating mice with allergic rhinitis(AR)as well as its mechanism.METHODS 48 BALB/c mice were randomly divided into normal group,model group, Xiaofeng Xuanqiao Decoction group and montelukast group,with 12 mice in each group.OVA sensitized mice were established as the model with gavage for 1 week.Nasal symptom scores,weight,weight of thymus and spleen index,nasal mucosa chan-ges,serum total IgE,ova specific IgE and IL-4,IL-17,IL-33,IFN-γlevels in the thymus of mice were observed.RESULTS Xiaofeng Xuanqiao Decoction could significantly reduce nasal symptoms of AR in mice,reduce the increased weight,thymus weight and thymus index caused by allergic reaction.Besides,it could significantly reduce serum total IgE and ova specific IgE level,and inhibit the production of thymus IL-4,IL-17,IL-33,IFN-γ.In reducing the thymus IL-33 level,Xiaofeng Xuanqiao decoction was better than western medicine montelukast group.CONCLUSION Xiaofeng Xuanqiao Decoction has definite effects for AR in mice.The anti AR effects can be achieved by inhibiting the level of thymic cytokine.
