Effects of different anesthesia methods on postoperative TLR4 expression and serum S100β protein level in children
10.7619/jcmp.201805018
- VernacularTitle:不同麻醉方法对手术后小儿Toll样受体4表达及血清S100β蛋白水平的影响
- Author:
Yanlin ZHU
1
;
Sanping YAN
;
Dongjun WANG
;
Can LIN
;
Mingji LIU
;
Yaou JIANG
Author Information
1. 江苏省靖江市人民医院麻醉科
- Keywords:
anesthetic methods;
Toll like receptor 4;
S100β protein;
adverse reactions;
ketamine;
sevoflurane
- From:
Journal of Clinical Medicine in Practice
2018;22(5):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of different anesthesia methods on postoperative TLR4 expression and the level of serum S100β protein in children.Methods Totally 122 children with elective surgery were randomly divided into two groups.The control group was treated with ketamine intravenous anesthesia,while the observation group was treated with inhalation anesthesia with sevoflurane.Expression of TLR4,the level of serum S100β protein and the adverse reactions of anesthesia were observed.Results During the period of anesthesia,the incidence rates of physical and mental symptoms in the observation group were significantly lower than the control group (P ＜ 0.05).The levels of serun S100β protein at 2 h and 24 h after operation in the observation group were significantly lower than those in the control group (P ＜ 0.05).Compared with those before operation,there was no significant difference in the expression of TLR4 at the time of skin incision,2 h and 24 h after operation (P ＞ 0.05).The expressions of TLR4 at the time points of after skin incision,2 h and 24 h after operation in the control group were significantly lower than those before operation and the observation group (P ＜ 0.05).Conclusion The sevoflurane inhalation anesthesia can reduce the adverse reactions of anesthesia in children with surgery.
